Letrozole for Fertility: Uses and Side Effects

There may be an increased risk of osteoporosis from taking letrozole. Letrozole might be used to help prevent breast cancer in certain high-risk post-menopausal women. Estrogen levels tend to be higher in women who drink alcohol than those who don’t. Since letrozole reduces estrogen levels, you may want to limit your alcohol consumption while taking it. In general, though, there aren’t any specific foods to avoid while taking letrozole, unless otherwise indicated by your healthcare provider. Some foods and supplements may tend to raise estrogen levels.

• Breast cancer cells may form a tumor in the breast and spread to other areas of the body.
• In the adjuvant trial (BIG 1-98) the incidence of bone fractures at any time after randomization was 14.7% for letrozole and 11.4%for tamoxifen at a median follow-up of 96 months.
• This change happens mainly in fatty tissue, muscle and the skin.
• Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of cardiovascular disease at any time after randomization was 14.4% for letrozole and 9.8% for placebo.

Use In Extended Adjuvant Treatment Of Early Breast Cancer

So, check with your doctor about the dosage of letrozole for infertility that’s recommended for you. They can also answer other questions related to using this drug for infertility. But before starting any new medications, be sure to talk with your doctor or pharmacist.

For how long should I take Letzol 2.5 Tablet?

Other studies suggest that compared to women who took Clomid, women who took letrozole had higher rates of ovulation, pregnancy, and live birth. Letrozole is also an option for people who experience Clomid resistance. Clomid, or clomiphene citrate, is another common oral medication used for infertility.

3DFS events defined as earliest of loco-regional recurrence, distant metastasis, contralateral breast cancer or death from any cause, and ignoring switches to letrozole in 60% of the placebo arm. Censored analysis censors follow-up at the date of selective crossover in 632 patients who crossed to letrozole or another aromatase inhibitor after the tamoxifen arms were unblinded in 2005. The primary endpoint of this trial was DFS (i.e., interval between randomization and earliest occurrence of a local, regional, or distant recurrence, or invasive contralateral breast cancer, or death from any cause). The secondary endpoints were overall survival (OS), systemic disease-free survival (SDFS), invasive contralateral breast cancer, time to breast cancer recurrence (TBR) and time to distant metastasis (TDM).

The safety and effectiveness in pediatric patients have not been established. An interaction study (P017) with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics. No dosage adjustment is required for patients with renal impairment if creatinine clearance is greater than or equal to 10 mL/min see Clinical Pharmacology (12.3).

If these affect your jaw, it’s possible the pain could spread and feel like tooth pain. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which Testosterone enanthate can cause trouble breathing.

You shouldn’t take letrozole while you’re pregnant or breastfeeding. You should also avoid becoming pregnant or breastfeeding for at least 3 weeks after your last dose of the drug. Letrozole may be used with other therapies in your breast cancer treatment plan. Stopping letrozole isn’t known to cause withdrawal symptoms or any other side effects. But be sure to talk with your doctor before stopping this drug. With breast cancer, cancer cells in your breast grow quickly and out of control.

Letrozole tablets are indicated for the extended adjuvant treatment of early breast cancer in postmenopausal women, who have received 5 years of adjuvant tamoxifen therapy. Extended adjuvant treatment in postmenopausal women with early-stage breast cancer who have received 5 years of adjuvant tamoxifen therapy. Efficacy of letrozole as extended adjuvant therapy based on analysis of disease-free survival in patients receiving the drug for a median of 5 years.